发明名称 |
Nanoparticle formulated glycolipid antigens for immunotherapy |
摘要 |
A composition for stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells includes a glycolipid antigen and a nanoparticle conjugated with the glycolipid antigen. The glycolipid antigen and the nanoparticle are not antigenic in mouse and human being. The composition can further include covalent or non-covalent connection between the glycolipid antigen and the nanoparticle. The glycolipid antigen is alpha-galactosylceramide or an analog of that. The nanoparticle can be a polymer. A production method of the composition includes preparing a nanoparticle and a glycolipid antigen and loading the glycolipid antigen to the nanoparticle. The glycolipid antigen can be coated onto the surface of the nanoparticle or encapsulated within the nanoparticle. A method of stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells is also provided.
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申请公布号 |
US8546371(B2) |
申请公布日期 |
2013.10.01 |
申请号 |
US201113188642 |
申请日期 |
2011.07.22 |
申请人 |
ZHOU DAPENG;LI CHUN;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
ZHOU DAPENG;LI CHUN |
分类号 |
A01N43/00;A61K31/33 |
主分类号 |
A01N43/00 |
代理机构 |
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