| 发明名称 |
Peripheral opioid receptor antagonists and uses thereof |
| 摘要 |
The present invention provides a compound of formula I: wherein R1, R2, R2' and X' are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
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| 申请公布号 |
US8546418(B2) |
申请公布日期 |
2013.10.01 |
| 申请号 |
US20080593619 |
申请日期 |
2008.03.28 |
| 申请人 |
AVEY ALFRED A.;CHANDRASEKAREN APPAVU;DOSHAN HAROLD D.;PEREZ JULIO;ROTSHTEYN YAKOV;PROGENICS PHARMACEUTICALS, INC.;WYETH, LLC |
发明人 |
AVEY ALFRED A.;CHANDRASEKAREN APPAVU;DOSHAN HAROLD D.;PEREZ JULIO;ROTSHTEYN YAKOV |
| 分类号 |
A61K31/485;C07D489/02 |
主分类号 |
A61K31/485 |
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