发明名称 |
POLYCYCLIC SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION |
摘要 |
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.
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申请公布号 |
CA2504694(C) |
申请公布日期 |
2013.10.01 |
申请号 |
CA20032504694 |
申请日期 |
2003.11.04 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
ALLERSON, CHARLES;BHAT, BALKRISHEN;ELDRUP, ANN B.;MANOHARAN, MUTHIAH;GRIFFEY, RICHARD;BAKER, BRENDA F.;SWAYZE, ERIC E. |
分类号 |
C07H21/04;A61K48/00;C07H21/00;C07H21/02;C08G;C12N15/113;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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