发明名称 |
Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] |
摘要 |
The invention relates to the synthesis of carbonitrile derivatives of spiro[cyclopropane-oxindoles], which can serve as precursors in the synthesis of substances with anti-HIV activity.The process involves the reaction of cyclopropanation of diazoisatins with acrylonitrile, used both as reagent and solvent at its boiling point.The proposed process allows of carrying out the reaction in a shorter time with high yields, without the use of catalysts and inert atmosphere. |
申请公布号 |
MD4201(C1) |
申请公布日期 |
2013.09.30 |
申请号 |
MD20120000030 |
申请日期 |
2012.03.21 |
申请人 |
INSTITUTUL DE CHIMIE AL ACADEMIEI DE STIINTE A MOLDOVEI |
发明人 |
SUCMAN NATALIA;MACAEV FLIUR |
分类号 |
C07D209/02;A61P31/18;C07C13/04;C07C253/30;C07C255/08;C07C255/47;C07D209/34;C07D209/56;C07D209/96 |
主分类号 |
C07D209/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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