SOLID ORAL FORMULATIONS OF A PYRIDOPYRIMIDINONE

摘要

594035 Disclosed is a pharmaceutical formulation comprising (a) (R)-2-amino-7-[4-fluoro-2-(6-methoxy-pyridin-2-yl)-phenyI]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one or a pharmaceutically acceptable salt thereof which is optionally micronized to a median particle size of about 10 nm to about 40 microns; and at least one (b) a surfactant, (c) or an acid, When the surfactant is vitamin E TPGS, it may be processed by direct blending. The acid is preferably an organic acid such as succinic acid.