PROCESS FOR THE PREPARATION OF 1-ARYL-PYRAZOL-3-ONE INTERMEDIATES USEFUL IN THE SYNTHESIS OF SIGMA RECEPTORS INHIBITORS

摘要

603864 Disclosed herein is a process for preparing 1-naphthyl-pyrazol-3-one intermediates of formulae VII and VIII, wherein the variables are defined in the specification , tautomers, and salts thereof, intermediates thereof, and the use of the intermediates in the preparation of sigma receptor inhibitors. The process comprises coupling of a carboxylic acid with a hydrazine, optionally in the presence of a coupling agent such as a carbodiimide or benzotriazole coupling agent.