NEW MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY

摘要

The disclosure relates to maytansinoid compounds of formula (I) which are cytotoxic agents, wherein the variables are as defined in the specification. The disclosure also relates to the use of said maytansinoids to prepare conjugates with an antibody having an affinity for tumor cells. The conjugate and also the compound of formula (I) can be used as anticancer agents, because the antibody makes it possible to have an agent that is selective towards the tumour cells, thus targeting the maytansinoid to a close vicinity of said cells or directly within them, which makes them suitable for treating solid and liquid tumours.