发明名称 |
METHOD FOR ASSESSING DRUG EFFECT ON PERMEABILITY OF CELL MEMBRANES BY SODIUM |
摘要 |
FIELD: medicine.SUBSTANCE: invention describes a method for assessing the drug effect on the permeability of the red-cell membranes by sodium with using the determination of a Na-Li-exchange transport rate in the red-cell membrane whereat an intracellular lithium exchange rate in the lithium-loaded cells by extracellular sodium from an incubation medium with the analysed substance introduced into a 1-hour incubation medium containing, mM: 150 - NaCl; 10 - glucose; 10 - Hepes-Tris; 0.1 - oubaine, and the varying Na-Li-exchange transport rate in the red-cell membrane enabling describing the effect of the substance on the permeability of the cell membranes by sodium.EFFECT: invention provides optimising the drug therapy selection.6 dwg, 1 tbl, 1 ex |
申请公布号 |
RU2494403(C2) |
申请公布日期 |
2013.09.27 |
申请号 |
RU20120101527 |
申请日期 |
2012.01.16 |
申请人 |
GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "KAZANSKIJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIVERSITET"MINISTERSTVA ZDRAVOOKHRANENIJA I SOTSIAL'NOGO RAZVITIJA ROSSIJSKOJ FEDERATSII;OSLOPOV VLADIMIR NIKOLAEVICH;ORLOVA OL'GA VALERIANOVNA |
发明人 |
OSLOPOV VLADIMIR NIKOLAEVICH;ORLOVA OL'GA VALERIANOVNA |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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