Drug useful e.g. for preparing composition and dietary supplement e.g. functional food and dietary product, and treating and/or preventing infertility and menstrual disorders, and increasing fertility, comprises ecdysone derivatives

摘要

Drug comprises ecdysone derivatives (I). Drug comprises ecdysone derivatives of formula (I) or their stereoisomers, tautomers or salts, or inclusion compounds. R1, R2 : alkyl, cycloalkyl, cycloalkyl-0-9C alkyl, alkenyl, alkynyl, acyl or aryl (all optionally substituted), H, OR11 or OR21; R11 : R1; R21 : R2; R3 : C(R4)(R5)K1; R4, R5 : cycloalkyl, cycloalkyl-0-9C alkyl, acyl or aryl (all optionally substituted), H, 1-4C alkyl, 1-4C alkenyl or 1-4C alkynyl; K1 : OH, SH, NH 2 or NHR6; R6 : 1-4C alkyl or 1-4C alkenyl; A : O, S, NH or N-R7; W1, X, Y1 : H, OH, SH, NH 2 or NHR8; R7, R8 : R6; and Z : cycloalkyl, cycloalkyl-0-9C alkyl, acyl or aryl (all optionally substituted), H, OH, SH, NH 2, 1-4C alkyl, 1-4C alkenyl or 1-4C alkynyl. [Image] ACTIVITY : Anabolic; Antiinfertility; Gynecological; Contraceptive; Endocrine-Gen. The ability of (I) to increase fertility was tested in sexually mature female rats by treating rats with diet containing (I) (in a daily intake of 22.5 mg/animal) for 4 weeks and mating the treated rats with fertile male rats. The results showed that (2S,3R,5R,9R,10R,13R,14S,17R)-17-(2,5-Dihydroxy-1,5-dimethyl-hexyl)-2,3,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-6-one increased the fertility of the test group (produced 83 female and 115 male newborn rats), compared to control group (produced 36 female and 39 male newborn rats). MECHANISM OF ACTION : None given.