CRYSTALLINE AND NON- CRYSTALLINE FORMS OF TOFACITINIB, AND A PHARMACEUTICAL COMPOSITION COMPRISING TOFACITINIB AND A PENETRATION ENHANCER.

摘要

The present invention discloses novel crystalline and non-crystalline forms of 3-((3R, 4R)-4-methyl-3-[methyl-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl)-3-oxopropionitrile, pharmaceutical composition containing the same, preparations thereof and the uses thereof.