| 摘要 |
<p>Human papillomavirus 16 (HPV16) is identified as a cause of epilepsy. This application is directed to HPV16-related epilepsy, methods of detection and prenatal prevention, and immunogenic, therapeutic and prophylactic compositions for same. The methods of predicting or detecting human papillomavirus (HPV16)-associated epilepsy may comprise contacting a biological sample obtained from a human subject, said human subject having experienced one or more seizures, with a diagnostic reagent that can detect HPV16 or an antigen thereof, or a humoral or cell-mediated response to HPV16 or an antigen thereof, in said biological sample, wherein the presence of HPV16 or an antigen thereof or a humoral or cell-mediated response to HPV16 or an antigen thereof, is indicative of HPV16-associated epilepsy. Also provided are parallel methods of diagnosing a structural brain defect in a subject having one or more seizures.</p> |
