发明名称 |
SYSTEMS, METHODS, AND DEVICES FOR ULTRASONIC ASSESSMENT OF CANCER AND RESPONSE TO THERAPY |
摘要 |
Microbubbles can be injected into the bloodstream of a patient, for example, a cancer patient undergoing a treatment specifically targeting a biological process in a tumor. The injected microbubbles can act as vascular contrast agents, which can be detected in vivo using high-frequency ultrasound imaging. The microbubbles can have a surface chemistry that allows them to bind to molecular targets in the tumor vasculature. After injection, the microbubbles can selectively adhere to endothelia expressing a target receptor. The selective adhesion can be used to quantify the tumor vasculature in vivo. By imaging the adhered microbubbles with ultrasound, an indication of how tumor vasculature is affected by a specific cancer treatment can be obtained. Such techniques can be used in a clinical setting for rapid determination of anti-cancer treatment efficacy for individual patients.
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申请公布号 |
US2013251633(A1) |
申请公布日期 |
2013.09.26 |
申请号 |
US201113813236 |
申请日期 |
2011.08.05 |
申请人 |
BORDEN MARK ANDREW;KANDEL JESSICA;SIRSI SHASHANK RAMESH;YAMASHIRO DARRELL;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
BORDEN MARK ANDREW;KANDEL JESSICA;SIRSI SHASHANK RAMESH;YAMASHIRO DARRELL |
分类号 |
A61K49/22 |
主分类号 |
A61K49/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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