发明名称 |
COLLATERAL GENE INACTIVATION BIOMARKERS AND TARGETS FOR CANCER THERAPY |
摘要 |
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor. In some aspects, a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor. |
申请公布号 |
WO2013090732(A3) |
申请公布日期 |
2013.09.26 |
申请号 |
WO2012US69767 |
申请日期 |
2012.12.14 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
MULLER, FLORIAN, L.;FLETCHER-SANANIKONE, ELIOT;COLLA, SIMONA;AQUILANTI, ELISA;DEPINHO, RONALD |
分类号 |
A61K48/00;A61K31/7088;A61K31/7105;A61P35/00 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|