| 发明名称 |
METHOD FOR THE PRODUCTION OF AMINO CROTONYL COMPOUNDS |
| 摘要 |
<p>An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.</p> |
| 申请公布号 |
EP1678165(B1) |
申请公布日期 |
2013.09.25 |
| 申请号 |
EP20040765927 |
申请日期 |
2004.10.12 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
RALL, WERNER;SOYKA, RAINER;KULINNA, CHRISTIAN;SCHNAUBELT, JUERGEN;SIEGER, PETER |
| 分类号 |
C07D405/12;A61K31/505;A61K31/517;A61P35/00 |
主分类号 |
C07D405/12 |
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