ANTIBODIES AGAINST GREMLIN-1

摘要

PURPOSE: An antibody against gremlin-1 is provided to suppress cell migration, cell invasion, and cell proliferation depending on gremlin-1, thereby treating cancer or immune diseases. CONSTITUTION: An antibody against gremlin-1 is provided. The antibody has anticancer effect by suppressing gremlin-1 in a bone morphogenetic protein (BMP) or vascular endothelial growth factor receptor-2 (VEGFR2) independent mode. The antibody is selected among an immune antibody, a chimera antibody, a human antibody, and a humanized antibody. Gremlin-1 is directly conjugated to cancer cells by the antibody.