发明名称 |
PROCESS FOR THE PREPARATION OF SALMETEROL AND ITS SALTS |
摘要 |
The present invention relates to processes for the preparation of 4-hydroxy-±'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-±'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (11), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (7), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (5), shown below, wherein X is a leaving group and Pg is a protecting group. |
申请公布号 |
EP2641893(A1) |
申请公布日期 |
2013.09.25 |
申请号 |
EP20130154981 |
申请日期 |
2006.10.17 |
申请人 |
GENERICS [UK] LIMITED |
发明人 |
GORE, VINAYAK, G.;GAIKWAD, AVINASH, C.;GADAKAR, MAHESHKUMAR, SURYAKANT;SHUKLA, VINAY, KUMAR |
分类号 |
C07C213/08;C07C41/16;C07C43/172;C07C43/174;C07C217/10 |
主分类号 |
C07C213/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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