Binding molecules

摘要

The present invention relates to a binding polypeptide complex comprising a dimer of a first heavy chain and a second heavy chain wherein:
each heavy chain comprises a binding domain, an effector moiety and a dimerisation domain;
the binding domain in the first heavy chain is either of the same specificity as, or of a different specificity from, the specificity of the binding domain in the second heavy chain;
the effector moiety in the first heavy chain has the same or different function from the effector moiety on the second heavy chain; and
each dimerisation domain comprises at least C H 2, C H 3 and optionally C H 4 antibody constant domains derived from the any class of immunoglobulin heavy chain gene.