Modulation of gene expression by oligomers targeted to chromosomal DNA
摘要
<p>Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.</p>
申请公布号
EP2641970(A1)
申请公布日期
2013.09.25
申请号
EP20130162209
申请日期
2006.11.13
申请人
THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人
COREY, DAVID REID;SHAMES, DAVID S.;JANOWSKI, BETHANY A.;MINNA, JOHN D.
