发明名称 |
RECOMBINANT VIRAL VECTORS FOR PREVENTION AND PROTECTION AGAINST ALPHAVIRUS INFECTION |
摘要 |
<p>This invention addresses how to rapidly prevent alphavirus-induced encephalitides before and after exposure to alphaviruses. The invention discloses a single dose administration of two types of recombinant viral vectors: one expressing interferon and another expressing the structural proteins of alphaviruses or a single dose administration of the recombinant viral vector co-expressing both interferon and the structural proteins of alphaviruses. This invention can be used to prevent humans from alphvirus-induced encephalitides in the event of a bioterrorism attack or biowarfare in which alphaviruses such as Venezuelan (VEEV), eastern (EEEV) and western (WEEV) equine encephalitis viruses are deliberately released to humans, a natural outbreak of alphaviruses, and an accidental exposure to alphaviruses in laboratory.</p> |
申请公布号 |
EP2114459(B1) |
申请公布日期 |
2013.09.25 |
申请号 |
EP20080714665 |
申请日期 |
2008.02.22 |
申请人 |
HER MAJESTY THE QUEEN, IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF NATIONAL DEFENCE |
发明人 |
WU, JOSH QIAOHUA;NAGATA, LESLIE P. |
分类号 |
A61K38/21;A61K35/76;A61K39/12;A61K39/39;C07K14/005;C12N7/00;C12N15/86 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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