| 发明名称 |
Combination of herpes simplex virus and chemotherapy for treating cancer |
| 摘要 |
<p>The present invention is directed to novel methods of enhancing the effectiveness of DNA damaging agents by exposing cells to viruses prior to or during exposure to the damaging agent. In certain embodiments of the invention, the DNA damaging agent is ionizing radiation, the virus is an adenovirus, and the increase in cell killing is synergistic when compared to radiation alone.</p> |
| 申请公布号 |
EP0862445(B8) |
申请公布日期 |
2013.09.25 |
| 申请号 |
EP19960934086 |
申请日期 |
1996.10.07 |
| 申请人 |
ARCH DEVELOPMENT CORPORATION;DANA-FARBER CANCER INSTITUTE |
发明人 |
HALLAHAN, DENNIS, E.;WEICHSELBAUM, RALPH, R.;KUFE, DONALD;SIBLEY, GREGORY, S.;ROIZMAN, BERNARD |
| 分类号 |
A61K35/76;A61K51/00;A61K31/00;A61K31/40;A61K31/70;A61K45/00;A61K45/06;A61K48/00;A61N5/10;A61P35/00;C12Q1/70 |
主分类号 |
A61K35/76 |
| 代理机构 |
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代理人 |
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| 地址 |
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