METHOD FOR CAREFULLY PRODUCING ULTRAFINE PARTICLE SUSPENSIONS AND ULTRAFINE PARTICLES AND USE THEREOF

摘要

The invention relates to a multistage process in order to produce, in a very effective and careful manner, particles having an average particle size of 50 nm to 1000 nm, during which the solid substance (active substance) is dissolved in a solvent, and this liquid containing the solid substance (active substance) in dissolved form is then rapidly frozen. The solvent(s) used are removed from the obtained frozen matrix optionally during a (freeze)-drying process (lyophilization) or the frozen matrix is subjected to a direct subsequent processing. The solid matrix is dispersed in an outer phase and the resulting dispersion is then immediately subjected to high shear and/or cavitation forces. The forces used lead to a stabilization or reduction in size of the resulting particles on the nanometric scale.