发明名称 |
Method for selectively crystallizing a Z isomer of iopromide |
摘要 |
The present invention relates to a method for selectively crystallizing Z isomer of iopromide of formula (I) comprising a) dissolving a crude iopromide comprising a mixture of E and Z isomers or a concentrate thereof in an alcohol, and b) heating the resulting alcohol solution to obtain crystalline of Z isomer of iopromide; and a method for preparing a composition comprising the crystalline Z isomer of iopromide.
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申请公布号 |
US8541620(B2) |
申请公布日期 |
2013.09.24 |
申请号 |
US200913132791 |
申请日期 |
2009.10.21 |
申请人 |
CHOI SOO-JIN;LEE BYUNG-GOO;LEE HAN-KUK;LIM YOUNG-MOOK;KIM WOL-YOUNG;LEE JOON-HWAN;DAEWOONG PHARMACEUTICAL CO., LTD. |
发明人 |
CHOI SOO-JIN;LEE BYUNG-GOO;LEE HAN-KUK;LIM YOUNG-MOOK;KIM WOL-YOUNG;LEE JOON-HWAN |
分类号 |
C07C233/65;A61K31/16;C07C233/05 |
主分类号 |
C07C233/65 |
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