发明名称 |
STABLE ISOTONIC LYOPHILIZED PROTEIN FORMULATION |
摘要 |
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein. |
申请公布号 |
PT1516628(E) |
申请公布日期 |
2013.09.24 |
申请号 |
PT20040022777T |
申请日期 |
1996.07.23 |
申请人 |
GENENTECH, INC. |
发明人 |
JAMES ANDYA;CHUNG C. HSU;JANET YU-FENG YANG;SYLVIA SAU-YAN WU;JEFFREY L. CLELAND;XANTHE M. LAM;DAVID E. OVERCASHIER;STEVEN J. SHIRE |
分类号 |
A61K38/00;A61K39/00;A61K39/395;C07K1/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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