发明名称 |
DRUG CARRIER AND DRUG CARRIER KIT FOR INHIBITING FIBROSIS |
摘要 |
An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited. |
申请公布号 |
CA2595517(C) |
申请公布日期 |
2013.09.24 |
申请号 |
CA20052595517 |
申请日期 |
2005.12.22 |
申请人 |
SAPPORO MEDICAL UNIVERSITY |
发明人 |
NIITSU, YOSHIRO;KATO, JUNJI;SATO, YASUSHI |
分类号 |
A61K47/10;A61K9/107;A61K9/127;A61K9/50;A61K9/51;A61K31/7088;A61K45/00;A61K47/14;A61K48/00;A61P43/00 |
主分类号 |
A61K47/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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