| 发明名称 |
Production of human antibodies using NOD/SCID/gammacnull mice |
| 摘要 |
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor gamma-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
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| 申请公布号 |
US8541033(B2) |
申请公布日期 |
2013.09.24 |
| 申请号 |
US20090620469 |
申请日期 |
2009.11.17 |
| 申请人 |
ITO MAMORU;KOBAYASHI KIMIO;NAKAHATA TATSUTOSHI;TSUJI KOICHIRO;HABU SONOKO;KOYANAGI YOSHIO;YAMAMOTO NAOKI;SUGAMURA KAZUO;ANDO KIYOSHI;NOMURA TATSUJI;CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS |
发明人 |
ITO MAMORU;KOBAYASHI KIMIO;NAKAHATA TATSUTOSHI;TSUJI KOICHIRO;HABU SONOKO;KOYANAGI YOSHIO;YAMAMOTO NAOKI;SUGAMURA KAZUO;ANDO KIYOSHI;NOMURA TATSUJI |
| 分类号 |
A61K35/28;A01K67/00;A01K67/027;A61K39/00;C12N5/08;C12N15/12;C12P21/00 |
主分类号 |
A61K35/28 |
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