G-PROTEIN COUPLED RECEPTORS AND USES THEREFOR

摘要

The invention provides isolated nucleic acids molecules, designated flh84g5 nucleic acid molecules, which encode polypeptides having high sequence homology to G-protein coupled receptors. The invention also provides antisense nucleic acid molecules, expression vectors containing flh84g5 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which an flh84g5 gene has been introduced or disrupted. The invention still further provides isolated flh84g5 polypeptides, fusion polypeptides, antigenic peptides, and anti-flh84g5 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.