发明名称 |
METHODS TO INCREASE OR DECREASE BONE DENSITY |
摘要 |
The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for identifying such molecules. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis.
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申请公布号 |
CA2476410(C) |
申请公布日期 |
2013.09.24 |
申请号 |
CA20032476410 |
申请日期 |
2003.02.28 |
申请人 |
CELLTECH R & D, INC. |
发明人 |
KUNG SUTHERLAND, MAY S.;GEOGHEGAN, JAMES C.;YU, CHANGPU;LATHAM, JOHN |
分类号 |
C12N15/12;G01N33/50;A61K31/557;A61K31/5575;A61K31/56;A61K31/57;A61K31/573;A61K31/575;A61K31/58;A61K31/7088;A61K31/7105;A61K38/00;A61K38/40;A61K48/00;A61P19/10;C07K14/47;C12N15/09;C12N15/113;C12Q1/02;C12Q1/04;C12Q1/68;G01N33/15;G01N33/53 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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