| 摘要 |
PURPOSE: A pharmaceutical composition for preventing or treating non-alcoholic fatty liver disease (NAFLD) is provided to prevent accumulation of triglyceride, thereby basically preventing and treating NAFLD. CONSTITUTION: A pharmaceutical composition for preventing or treating NAFLD contains an insulinotropic peptide drug conjugate in which insulinotropic peptides are conjugated with an immunoglobulin Fc region through a non-peptidyl polymer. The insulinotropic peptides are selected among exendin-4, an exendin-4 derivative in which an N-terminal amine group of exendin-4 is removed, an exendin-4 derivative in which the N-terminal amine group of exendin-4 is substituted with a hydroxyl group, an exendin-4 derivative in which the N-terminal amine group of exendin-4 is modified with a dimethyl group, and an exendin-4 derivative in which alpha carbon of an N-terminal histidine residue and alpha carbon-conjugated N-terminal amine group are removed. The non-peptidyl polymer is selected among polyethylene glycol, polypropylene glycol, an ethylene glycol-propylene glycol copolymer, polyoxyethylated polyol, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and a combination thereof. |
