| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel pyrimidine derivatives of general formula(I), or pharmaceutically acceptable salts thereof, where Xdenotes N, N-R, C-Ror O; Xdenotes N, CH or C-CH; Xdenotes N or C, where X, Xand Xall do not simultaneously denote N; X, Xeach independently denotes C or N; Xdenotes N or C-R; where at least two and not more than four of X, X, X, X, Xand Xdenotes N; and where the bonds between Xand X, Xand X, Xand X, Xand X, Xand X, as well as Xand Xcan each independently be single or double, or , can form an aromatic ring, under the condition that a chemically stable structure is formed; R denotes -(cyclohexyl)R; Rdenotes a halide, nitro group, -CN, -CHCN, -OH, -NH, -COOH or -YR; Ydenotes -O-, -SO, -NHSO-, -C(O)O- or a bond; Rdenotes (C-C)alkyl, phenyl or benzyl, each of which is substituted with 0-3 times with a hydroxy group or a halogen; n equals 0, 1 or 2; Rdenotes H or (C-C)alkyl; Rdenotes H, -OH, =O or -Y-Y-Y-R, where Ydenotes -C(O)-, -C(O)NR-, -NH- or a bond; Ydenotes (C-C)alkylene or a bond; Ydenotes -NR-, -S-, -SO-, -NRC(O)-, -NHSO- or a bond; Rdenotes (C-C)alkyl, (C-C)cycloalkyl, a 5-6-member heterocyclyl containing 1-2 heteroatoms selected from N and O, where Ris optionally substituted with -OH or -NHR; where each Rindependently denotes hydrogen or (C-C)alkyl; Z denotes hydrogen. The invention also relates to a pharmaceutical composition based on a compound of formula (I).EFFECT: obtaining novel pyrimidine derivatives which are useful for therapeutic or preventive treatment of a c-Jun N-terminal kinase-mediated disorder.14 cl, 3 tbl, 26 ex |
