| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel of 2,4-pyrimidine diamine compounds of formula I, which inhibit degranulation of immune cells and can be used in treating cell reactions mediated by Fc?RI or Fc?Rl receptors. In formula(I) each Rand Ris independently phenyl substituted with one or more Rgroups or a heteroaryl selected from a group consisting of, where the heteroaryl is optionally substituted with one or more Rgroups and at least one of Rand Ris a heteroaryl; Ris selected from a group consisting of (C1-C6)alkyl, optionally substituted with one or more identical or different Rgroups, -OR, -SR, fluorine, (C1-C3)halogenalkyloxy, (C1-C3)perhalogenalkyloxy, -NRR, (C1-C3)halogenalkyl, -CN, -NO, -C(O)R, -C(O)OR, -C(O)NRR, -C(NH)NRR, -OC(O)R, -OC(O)OR, -OC(O)NRR; -OC(NH)NRR, - [NHC(O)]OR, Ris hydrogen or R; each Y is independently selected from a group consisting of O, S and NH; each Yis independently selected from a group consisting of O, S and NH; each Yis independently selected from a group consisting of CH, CH, S, N, NH and NR. Other values of radicals are given in the claim.EFFECT: improved efficiency.19 cl, 6 tbl. |
