| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel carboxyl- or hydroxyl-substituted benzimidazole derivatives of formula(I), or pharmaceutically acceptable salts thereof, where Ris selected fromand, Ris hydrogen; Ris cyclohexyl or bicyclo[2.2.1]heptyl; Ris phenyl, which is substituted in the 4th position with a halogen or a lower fluoroalkyl, or a pyridyl, which is substituted with 1 or 2 substitutes independently selected from halogen and a lower alkoxy group; Rand Rindependently denote hydrogen or fluorine; Rand Rare independently selected from a group consisting of hydrogen, lower alkyl, halogen, lower alkoxy group, lower fluoroalkyl, lower fluoroalkoxy group and cyano group; Ris -(CRR)-COOH, where n equals 0, 1 or 2, and Rand Rare independently hydrogen or lower alkyl, or -O-(CRR)-COOH, where p equals 1 or 2, and Rand Rare independently hydrogen or lower alkyl, or Rand Rtogether with the carbon atom with which they are bonded form a cycloalkyl ring, or Ris tetrazole; Ris a hydroxy group or -(CH)-COOH, where p equals 0 or 1; m equals 0 or 1; Ris -COOH. The invention also relates to specific carboxyl- or hydroxyl-substituted benzimidazole derivatives and a pharmaceutical composition based on a compound of formula (I).EFFECT: novel carboxyl- or hydroxyl-substituted benzimidazole derivatives, having selective activity with respect to farnesoid X receptor, are obtained.26 cl, 126 ex |
