NEW POLYMORPHIC FORM OF A LONG-ACTING BETA-2 ADRENOCEPTOR AGONIST

摘要

New polymorphic form of a long-acting beta-2 adrenoceptor agonist A new polymorphic form of arformoterol tartrate, designated as form D, is provided and which is characterised by at least one of the following: (i) a powder X-ray diffraction pattern having peaks at approximately 6.8, 13.3, 13.6, 3.8, 14.1, 18.2, 18.7, 20.0 ±0.2 degrees two theta; or (ii) a DSC thermogram showing an endothermic peak with an onset at approximately 19-120 ºC, and a maximum at approximately 129-131 ºC, followed by an exothermic peak with a maximum at approximately 137-138 ºC; wherein the DSC thermogram of form D has a further endothermic peak with an onset at approximately 168-170 ºC.1 Processes for preparing the new polymorphic form, uses thereof and intermediates for the preparation thereof, are also provided.