INTEGRIN-TARGETED IMAGING OF INFLAMMATION IN VASCULAR REMODELING

摘要

The invention provides methods of assessing in real time the likelihood that a subject suffers from, or is risk of developing, a vascular disorder, the method comprising: (a) arterially administering a detectable ligand having a binding affinity for a?ß3 integrin to the subject, measuring the subject's vascular uptake of the detectable ligand, and comparing the subject's vascular uptake of the detectable ligand to a standard or control, wherein an increase in the subject's vascular uptake of the detectable ligand when compared to the standard or control sample indicates that the subject suffers from, or is risk of developing, a vascular disease; and optionally (b) imaging the subject's vascular walls to assess vascular wall remodeling. The invention also provides methods of assessing in real time the efficacy of vascular disorder treatments.