Benzoxepin P13K inhibitor compounds and methods of use

摘要

Abstract Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z' is 5 CR or N; Z2 is CR 2 or N; Z3 is CR 3 or N; Z4 is CR 4 or N; and where (i) X' is N and X2 is S, (ii) X1 is S and X2 is N, (iii) X' is CR7 and X2 is S, (iv) X' is S and X2 is CR 7; (V) XI is NR8 and X2 is N, (vi) X1 is N and X2 is NR 8, (vii) XI is CR7 and X2 is 0, (viii) X' is 0 and X2 is CR7 , (ix) XI is CR 7 and X2 is C(R7 )2, (x) X' is C(R 7)2 and X2 is CR 7; (Xi) XI is N and X2 is 0, or (xii) X, is 0 and X2 is N, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of 10 P13K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. 4478498_1 (GHMatters) P89947AU.] 5/08/13