AN EXPRESSION VECTOR COMPRISING A POLYNUCLEOTIDE ENCODING A MODIFIED GLUTAMINE SYNTHETASE AND A METHOD FOR PREPARING A TARGET PROTEIN EMPLOYING THE SAME

摘要

The present invention relates to a vector comprising a polynucleotide encoding a modified glutamine synthetase (GS), and a method for preparing a target protein employing the same. More particularly, the present invention relates to a modified GS having an increased sensitivity to a glutamine synthetase (GS) inhibitor, a polynucleotide encoding the modified GS, a vector comprising the polynucleotide, a transformant comprising the vector, and a method for preparing a target protein using the transformant.