Biomarker for motor neuron disease (MND)

摘要

A method of diagnosing or prognosing motor neuron disease (MND) is described which comprises detecting p75 neurotrophin receptor (p75NTR) or a fragment thereof (eg the extracellular domain; ECD) in a test body sample (eg whole blood and urine) from said subject, or otherwise detecting a change in the amount of p75NTR or a fragment thereof in a test body sample from said subject taken at two or more time points. Similar methods may be applied to the monitoring of MND progression or assessing the effectiveness of an MND therapy. A method of screening an agent that is capable of treating MND is also described.