APTZAYME CAPABLE OF SELECTIVE SILENCING OF TARGET miRNA BY RELEASING AN ANTISENSE SEQUENCE IN HEPATITIS C VIRUS-INFECTED CELLS AND USE THEREOF

摘要

The present invention relates to an aptazyme comprising an aptamer for hepatitis C virus (HCV) RNA-encoding component; a hammerhead ribozyme comprising an antisense sequence to microRNA at the site released by self-cleavage; and a communication module sequence that connects the aptamer and hammerhead ribozyme and triggers a self-cleavage activity of the hammerhead ribozyme upon binding of the aptamer with the HCV RNA-encoding component. The present aptazyme inhibits microRNA activity specifically in HCV proliferating cells and thus a composition of the present invention comprising the aptazyme can be effectively used for treatment of HCV-related diseases.