AMORPHOUS AND SOLVATED POLYMORPHOUS FORMS OF TIOTROPIUM IODIDE AND A METHOD THEIR PREPARATION

摘要

The invention relates to new polymorphous forms of tiotropium iodide of formula I and a method of their preparation, wherein a dichloromethane/acetonitrile solvate of tiotropium iodide of formula V is crystallized from water. The solution includes two new polymorphous forms of tiotropium iodide and an amorphous form of tiotropium iodide, including a method of their preparation.