发明名称 |
SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS |
摘要 |
In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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申请公布号 |
US2013245043(A1) |
申请公布日期 |
2013.09.19 |
申请号 |
US201213420333 |
申请日期 |
2012.03.14 |
申请人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;STAUFFER SHAUN R.;BARTOLOME-NEBREDA JOSE MANUEL;MACDONALD GREGOR JAMES;CONDE-CEIDE SUSANA;JONES CARRIE K.;LUZ MARTIN-MARTIN MARIA;TONG HAN MIN |
发明人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;STAUFFER SHAUN R.;BARTOLOME-NEBREDA JOSE MANUEL;MACDONALD GREGOR JAMES;CONDE-CEIDE SUSANA;JONES CARRIE K.;LUZ MARTIN-MARTIN MARIA;TONG HAN MIN |
分类号 |
A61K31/519;A61P3/04;A61P3/10;A61P25/00;A61P25/06;A61P25/08;A61P25/14;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P35/00;C07D487/04 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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地址 |
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