Genetic polymorphisms associated with Psoriasis, methods of detection and uses thereof

摘要

The present invention is based on the discovery of a single nucleotide polymorphism (SNP) in gene IL23R in the nucleotide sequences of SEQ ID NO:41 that is associated with psoriasis and related pathologies. In particular, the present invention relates to methods for identifying an individual who has an altered risk for developing psoriasis, and methods for determining whether an individual will likely benefit from treatment with a therapeutic agent targeting IL12 or IL23, based on the detection of said SNP. The present invention further relates to a therapeutic agent targeting IL12 or IL23 for use in a method of treating psoriasis based on the detection of said SNP.