发明名称 |
MODIFIED SHORT INTERFERING RNA (MODIFIED SIRNA) |
摘要 |
<p>The present invention is directed to modified siRNA which are significantly impaired in their ability to support cleavage of mRNA when incorporated into a RISC complex. Such modified siRNA may be useful as therapeutic agents, e.g., in the treatment of various cancer forms. More particularly, the modified siRNA comprises a sense strand and an antisense strand, wherein the sense strand contains a modified RNA nucleotide in at least one of positions 8-14, calculated from the 5'-end.</p> |
申请公布号 |
EP1713912(B1) |
申请公布日期 |
2013.09.18 |
申请号 |
EP20050700612 |
申请日期 |
2005.01.28 |
申请人 |
SANTARIS PHARMA A/S |
发明人 |
ELMEN, JOACIM;WAHLESTEDT, CLAES;LIANG, ZICAI;ORUM, HENRIK;KOCH, TROELS |
分类号 |
C12N15/113;A61K38/00;C12N15/11 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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