发明名称 |
Methods of reducing CRP and/or increasing serum albumin in patients in need using IL-6 antibodies of defined epitopic specificity |
摘要 |
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level or a reduced serum albumin level prior to treatment. In another preferred embodiment, the patient's Glasgow Prognostic Score will be increased and survivability will preferably be improved. |
申请公布号 |
US8535671(B2) |
申请公布日期 |
2013.09.17 |
申请号 |
US201113240181 |
申请日期 |
2011.09.22 |
申请人 |
SMITH JEFFREY T. L.;ALDERBIO HOLDINGS LLC |
发明人 |
SMITH JEFFREY T. L. |
分类号 |
A61K39/395;C07K16/24;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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