发明名称 Protein stabilization in solution
摘要 Provided are storage containers for proteinaceous pharmaceutical compositions which are characterized in, among other things, comprising (i) a wall portion, wherein an inner wall material thereof is selected from silica-coated glass, silicone-coated glass, polymers of non-cyclic olefins, cycloolefin polymers and cycloolefin/linear olefin copolymers and (ii) one or more closure portions not constituting part of the wall portion, and which contains a formulation of a protein. Also provided are new methods of storing proteinaceous compositions. In one aspect, the stored protein is characterized as having an amino-terminal gamma-carboxyglutamic acid (Gla) domain with 9-12 Gla residues.
申请公布号 US8536127(B2) 申请公布日期 2013.09.17
申请号 US20050284709 申请日期 2005.11.22
申请人 JENSEN MICHAEL BECH;HANSEN BIRTHE LYKKEGAARD;KORNFELT TROELS;JAKOBSEN KIRSTEN KRAMER;NOVO NORDISK HEALTHCARE AG 发明人 JENSEN MICHAEL BECH;HANSEN BIRTHE LYKKEGAARD;KORNFELT TROELS;JAKOBSEN KIRSTEN KRAMER
分类号 A61K38/48;A61K38/16;A61K38/43 主分类号 A61K38/48
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