发明名称 |
Antibacterial antisense oligonucleotide and method |
摘要 |
A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3' or 5' end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications.
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申请公布号 |
US8536147(B2) |
申请公布日期 |
2013.09.17 |
申请号 |
US20100723413 |
申请日期 |
2010.03.12 |
申请人 |
WELLER DWIGHT D.;GELLER BRUCE L.;IVERSEN PATRICK L.;TILLEY LUCAS D.;HASSINGER JED N.;SAREPTA THERAPEUTICS, INC. |
发明人 |
WELLER DWIGHT D.;GELLER BRUCE L.;IVERSEN PATRICK L.;TILLEY LUCAS D.;HASSINGER JED N. |
分类号 |
C07H21/02;A61K31/70;C07H21/04;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
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