| 发明名称 |
PI3 KINASE MODULATORS AND METHODS OF USE |
| 摘要 |
The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
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| 申请公布号 |
CA2694136(C) |
申请公布日期 |
2013.09.17 |
| 申请号 |
CA20082694136 |
申请日期 |
2008.08.01 |
| 申请人 |
AMGEN INC. |
发明人 |
BOOKER, SHON;D'ANGELO, NOEL;D'AMICO, DERIN C.;KIM, TAE-SEONG;LIU, LONGBIN;MEAGHER, KRISTIN;NORMAN, MARK H.;PANTER, KATHLEEN;SCHENKEL, LAURIE B.;SMITH, ADRIAN L.;TAMAYO, NURIA A.;WHITTINGTON, DOUGLAS A.;XI, NING;YANG, KEVIN |
| 分类号 |
C07D277/82;A61K31/423;A61K31/424;A61K31/428;A61K31/429;A61P35/00;C07D413/04;C07D417/04;C07D417/14;C07D513/04 |
主分类号 |
C07D277/82 |
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