STABLE PHARMACEUTICAL COMPOSITION CONTAINING DOCETAXEL AND A METHOD OF MANUFACTURING THE SAME

摘要

THE PRESENT INVENTION RELATES TO A STABLE PHARMACEUTICAL COMPOSITION FOR INJECTION CONTAINING DOCETAXEL AND A METHOD OF PREPARING THE SAME. MORE PARTICULARLY, THE PRESENT INVENTION RELATES TO A PHARMACEUTICAL COMPOSITION FOR INJECTION CONTAINING DOCETAXEL HAVING BETTER STORAGE STABILITY THAN CONVENTIONAL MEDICATIONS, WHICH IS PREPARED BY DISSOLVING DOCETAXEL, A WATER-INSOLUBLE COMPOUND, IN DISTILLED WATER AFTER MIXING IT WITH CYCLODEXTRIN (CD) AND A WATER-SOLUBLE POLYMER SUCH AS HYDROXYPROPYL METHYLCELLULOSE (HPMC), POLYETHYLENE GLYCOL (PEG) OR POLYVINYLPYRROLIDONE (PVP) AND LYOPHILIZING THE MIXTURE, AND A METHOD OF PREPARING THE SAME.