| 发明名称 |
4-HYDROXY-ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS |
| 摘要 |
<p>The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.</p> |
| 申请公布号 |
CA2866556(A1) |
申请公布日期 |
2013.09.12 |
| 申请号 |
CA20132866556 |
申请日期 |
2013.03.08 |
| 申请人 |
FIBROGEN, INC. |
发明人 |
HO, WEN-BIN;ZHAO, HONGDA;DENG, SHAOJIANG;NG, DANNY;WRIGHT, LEE R.;WU, MIN;ZHOU, XIAOTI;AREND, MICHAEL P.;FLIPPIN, LEE A. |
| 分类号 |
C07D217/26;A61K31/4725;A61P1/00;A61P9/10;A61P21/00;C07D401/12;C07D407/12;C07D409/12 |
主分类号 |
C07D217/26 |
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