| 摘要 |
PROBLEM TO BE SOLVED: To provide a method capable of manufacturing an α,α-difluoro aromatic compound (a CFgroup directly bonds to an aromatic ring) in which high yield cannot be expected, industrially at low cost, in good yield, without requiring a high toxic catalyst, with simple operation, and with the use of a simple reactor.SOLUTION: A method of manufacturing an α,α-difluoro aromatic compound includes a process to make 1-chloro-1-aromatic ring substitution ethenes react with " a salt or complex consisting of an organic base and hydrogen fluoride". 1-chloro-1-aromatic ring substitution ethenes and "the salt or complex consisting of an organic base and hydrogen fluoride" can be obtained at comparatively low cost and at a large-amount scale. Moreover, an adopted reaction condition is mild, thereby selectivity is high and yield is also excellent. Further, a high toxic catalyst is not needed, a reactor is simple, and operation is also convenient. The present invention is very useful in this manner as an industrial manufacturing method of the α,α-difluoro aromatic compound. |
