| 摘要 |
The present invention is directed to new compounds of formula (I) wherein R1 is OH, H, D or -0-C(0)-C1C6 alkyl; R2 is H or D; R3 and R4 is each and independently H or D; and R5, R6 and R7 is each and independently H or D; with the exception of the compounds (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5- (3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one (picropodophyllin) and (5R)-5,8,8a,9-Tetrahydro-5-(3,4,5- trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, [5R- (5. alpha., 5a. beta.,8a. alpha.)] (deoxypicropodophyllin). to a pharmaceutical composition comprising said compounds, and to the use of said compounds in therapy. |
