发明名称 |
ANTIBODIES SPECIFIC FOR SOLUBLE AMYLOID BETA PEPTIDE PROTOFIBRILS AND USES THEREOF |
摘要 |
The invention relates to an isolated monoclonal antibody or antigen-binding fragment thereof that (a) binds (i) wild-type Abeta 42/40 protofibril comprising N-terminal truncated Abeta forms and (ii) Abeta 42/40 Arc protofibril comprising N-terminal truncated Abeta forms and (b) has no or little cross-reactivity to Abeta 42/40 monomers. The invention further relates to a method of using such an antibody to treat Alzheimer's disease.
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申请公布号 |
US2013236452(A1) |
申请公布日期 |
2013.09.12 |
申请号 |
US201313780643 |
申请日期 |
2013.02.28 |
申请人 |
BIOARCTIC NEUROSCIENCE AB |
发明人 |
GELLERFORS PAER;LANNFELT LARS |
分类号 |
C07K16/18;A61K39/395;A61P25/28;C07K;C07K14/47 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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